Abstract
Introduction:
It is still debated whether hypothyroidism is an independent risk factor for cardiovascular events. Our objective was to evaluate the association between hypothyroidism and the risks of cardiovascular events and mortality through 3 stratification systems.
Methods:
A retrospective study was carried out by reviewing medical records in the period of January 2015 - December 2017 in a South American hospital. Geriatric patients who had fasting total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, and plasma glucose were included. Quantitative variables are presented as mean ± standard deviation or median (interquartile range) according to their distribution, and qualitative variables as percentages. Student's t test was performed to assess the differences between two variables. All statistical analyzes of the database results were performed with (SPSS for Windows, v.20.1; Chicago, IL).
Results:
The present study demonstrated that the presence of metabolic syndrome criteria in patients diagnosed with hypothyroidism is really high. The male gender was 32% compared to the female 68%. The Framingham equation classified a higher percentage of female patients with hypothyroidism as low cardiovascular risk compared to the PROCAM and SCORE equations. It was found that there was a greater cardiovascular risk in those patients with an uncontrolled hypothyroidism profile, showing a statistical correlation of said alteration for the 3 stratification systems used.
Conclusions:
Hypothyroidism is a risk factor for cardiovascular disease. Uncontrolled hypothyroidism in the present study is associated with greater adverse outcomes in the medium and long term, the present study warns about the need to better characterize these patient cohorts.