Abstract
Introduction
Orthopaedic surgery is an important treatment for musculoskeletal (MSK) conditions. In the NHS, 25% of all surgical interventions are for MSK conditions and account for 16.1% of the total cost of surgery. Complications following joint surgery include venous thromboembolism, infection, stroke, myocardial infarction, falls and delirium. Remote ischaemic conditioning (RIC) is a technique which induces intermittent ischaemia of a limb, through inflating a tourniquet above systolic blood pressure for intervals that avoid physical injury but trigger several intrinsic protective mechanisms.
Method
A systematic literature search was performed in Pubmed, Medline and Embase for studies investigating RIC in fracture, trauma or orthopaedic surgery, published between 1966 and November 2023. Pre-clinical trials and clinical randomised controlled trials (RCTs) were included. There was insufficient data to conduct meta-analyses, so a narrative review was undertaken. PEDro risk of bias scale was performed on RCTs.
Results
Three pre-clinical trials studied RIC in animal models. Results showed a reduction in markers of oxidative stress and up-regulation of genes involved in osteoblast expression, causing improved fracture healing. 20 clinical RCT manuscripts considered the used of RIC in elective and emergency orthopaedic surgery. In total, 1276 participants were studied, and protocols used one dose of RIC prior to surgery. 17 studies demonstrated statistically significant positive outcomes in RIC compared to control, including known mechanisms of RIC such as oxidative stress, inflammation and oxygenation. Additionally, when measured, post-operative pain was improved and there were fewer cardiovascular complications in at-risk individuals.
Conclusions
There is evidence that RIC has a positive effect in orthopaedic surgery, however the populations and outcomes measured were varied. Repeated use of RIC, including post-operative doses, may result in more profound beneficial effects. There is a need for designed RCTs to test whether this intervention can improve the clinical outcomes in wider populations.