The primary tauopathies are a group of neurodegenerative diseases causing motor and cognitive impairment. The onset of clinical symptoms in these disorders can be non-specific and subtle, making early diagnosis challenging. This talk will cover aspects of the clinical diagnosis and management of Progressive Supranuclear Palsy and Corticobasal Degeneration, before covering some recent advances in research. In particular, we will discuss how understanding the changes in brain structure and function using MRI and PET is helping to uncover potential mechanisms of disease.